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Here is the principle
Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, whereas semaglutide acts on GLP-1 receptors alone and tirzepatide targets both GIP and GLP-1 receptors
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However, despite their availability, adoption of medications for the management of obesity remains low [14, 15]
![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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