what is the best dose of tirzepatide for weight loss infographic compares 10 commonly discussed weight-loss medicines. and semaglutide produce the greatest average loss, but they can cause nausea, vomiting, constipation, gallstones and Tirzepatide Dosage Guide and Chart

And he mentions he's aware of it in "The Fry Cook Games"

Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded

Ongoing cardiovascular outcomes trials (SYNCHRONIZE-CVOT for Survodutide) will provide definitive data on whether these metabolic improvements prevent heart attacks, strokes, and cardiovascular death

Dan Cooper, professor emeritus at UC Irvine, urged caution when prescribing the medications to children and adolescents