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Apart from the beneficial effects and detrimental side effects of melanin production, melanocytes can also protect against microbial infections by acting as antigen-presenting cells producing cytokines, phagocytosing microorganisms, and degrading both phagocytosed bacteria and bacteria in the microenvironment by means of melanosomal lysosomal enzymes [4, 6, 7]

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For the 5 mg/kg IP injection, the estimated mean AUC by 3 h (AUC 03hr ) was 20.4 mgmin/mL, which accounted for more than 95% of the estimated total AUC (AUC 0- ) of 21.0 mgmin/mL

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