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One locus on chromosome 17p13 was the first genomic region linked to vitiligo associated with autoimmune diseases.8 And the positional cloning of the 17p13 region identified the NLRP1 gene as the likely source of the vitiligo linkage signal.9,10 Chromosome 22q12 has been associated with the pathogenesis of vitiligo,8,11 with the variants that regulate XBP1 gene expression being the risk factor indicated in the 22q12 region.12XBP1 is a transcription factor that regulates the expression of the HLA class II gene, being involved in cellular response to stress and often associated with autoimmune diseases
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