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In 2025, a landmark study revealed that patients with severe obesity lost an average of 11.9% of their body weight after a year of consistent injectable therapies like semaglutide
The rate of dropout in studies of oral semaglutide has been significant, approximately 25% in recent trials, reflecting tolerability concerns, mainly due to nausea (source)
If a peptide is reconstituted in sterile water for injection or another non-preserved solvent, the usable window may be much shorter and should be controlled by the protocol, supplier documentation, and sterility requirements
doi: 10.1016/j.phrs.2021.105840
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