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Moreover, the pharmacological agents such as the centrally acting gonadotrophin releasing analogs (cetrorelix and leuprolide), the peripherally acting drugs (aromatase inhibitors, antiprogestins), and the selective progesterone receptor modulators [5] have limited efficacy and are often associated with several adverse drug reactions [6,7]

The guideline also stresses careful patient selection, monitoring, and consideration of access, cost, and long-term use, Jenkinson said, potentially adding to logistical complications of widespread adoption

STEP was one of the largest clinical trial programs for obesity management

These effects typically emerge within the first 4-8 weeks of consistent use, with continued improvements over 6-12 months