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Research focused on period changes with Wegovy is limited, and standard prescribing information does not usually list irregular periods as a common direct adverse effect
The two primary incretin hormones are: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) These hormones support metabolic balance by stimulating insulin secretion, inhibiting glucagon release (which would otherwise raise blood sugar), slowing gastric emptying (to help regulate the pace of digestion), and promoting a feeling of fullness or satiety, which can reduce overall food intake
Infact in the sleeve gastrectomy the stomach is cut longitudinally, damaging the very distal branches of the gastric vagal nerve, while in the RYGB the stomach is cut transversely, resulting in a damage of the gastric vagal branches very close to their origin from the esophageal plexus (Ballsmider et al., The ANS as a therapeutic target in obesity Based on the physiopatological background above described, it is clear the modulation of ANS may induce weight loss and/or reduce cardiovascular risk in obese patients
Lets break down the differences between Tirzepatide and Retatrutide, focusing on their mechanisms, usage, and effectiveness
