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A step in this direction would be a treatment strategy designed to offset neuron losses by stimulating synaptogenesis in existing neurons and the formation of new functional neurons thus slowing disease progression

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There is no strong evidence favoring morning versus evening injections

By the time most patients are in their late 30s or 40s, pineal calcification and reduced melatonin synthesis have already begun degrading sleep architecture, particularly the slow-wave deep sleep phases where cellular repair, growth hormone release, and memory consolidation occur