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Similar results were found in several studies on the effects of metformin on the gut microbiota of patients with obesity or T2DM (de la Cuesta-Zuluaga et al., 2017

Fatigue may occur because the body is adjusting to treatment, but it may also reflect under-eating, low protein intake, dehydration, electrolyte changes, rapid weight loss, poor sleep, constipation, low blood sugar, low blood pressure, or another medical issue

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Results Adeno-Associated Viral Was Successfully Transfected and Continuously Expressed Four weeks after surgery, immunofluorescence analysis detected successful transfection signals in the spinal cord