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Dehydration from nausea and vomiting, electrolyte imbalances from reduced food intake, the physiological stress of rapid weight changes, interactions with caffeine, anxiety about taking a new medication, these are all factors that do not cleanly show up in trial adverse event tables but absolutely contribute to real-world palpitation experiences

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As this was happening, career FDA scientists quietly argued in posts shared on the FDA website that there had not yet been enough clinical human trials to confirm that the peptides in question are both safe and effective for pharmacies to compound and distribute