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Described as the first selective GHRP-receptor agonist. Bone Biology 1999 Bone-growth dissociated from IGF-1 (15-day rat model) Johansen and colleagues reported dose-dependent increases in longitudinal bone-growth rate in adult female rats after 15 days of ipamorelin administration, with total IGF-I and IGFBPs unchanged a dissociation of skeletal effects from the sustained IGF-1 axis in this short-duration preclinical model
The LEAD-1 study provided clinical input and compared glimepiride with two doses of liraglutide (1.2 mg and 1.8 mg) and rosiglitazone (4 mg) in patients with type 2 diabetes mellitus (T2DM) (16)
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Wang L, Cai H, Hu Y, Liu F, Huang S, Zhou Y, et al
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