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Data availability Data supporting the findings of this manuscript are available from the corresponding authors upon reasonable request

The GRADE methodology 72 was used to assess the quality of the body of retrieved evidence for the principal endpoint, with GRADEpro GDT software (GRADEpro Guideline Development Tool

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Debe rotar entre las tres zonas aprobadas (abdomen, muslo, brazo) y mantener al menos 2.5 cm de distancia del sitio anterior para prevenir lipohipertrofia y reacciones locales