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Patients should be advised to maintain consistent timing of levothyroxine administration and to report any symptoms suggestive of thyroid dysfunction, such as palpitations, tremor, anxiety (suggesting hyperthyroidism), or worsening fatigue and weight gain (suggesting hypothyroidism)

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The molecular basis for this selectivity difference is not fully characterized at the structural level but is attributed to ipamorelin's distinct binding mode at the receptor's orthosteric site, which appears to bias the downstream signaling cascade toward the GH-releasing pathway rather than the full spectrum of ghrelin receptor activity