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doi: 10.2174/1568010053622830 99 LiCPGauSYChenCCKaoCHTsaiRYYangHJ

Furthermore, the limited DNA repair capacity in mitochondria makes it difficult for mtDNA to recover from oxidative damage

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Finally, the recent discovery of OPC mechanosensitivity and of the impact of tissue stiffness on OLG maturation and myelination opens up new perspectives for treatment (Makhija et al., 2020), although we will need to understand much more about the mechanobiology of OPCs before translation into clinical practice