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Chronic diarrhea persisting beyond four weeks, even if mild, requires investigation to exclude conditions such as microscopic colitis, bile acid malabsorption, or exocrine pancreatic insufficiency

GLP-1 receptor agonists work through several mechanisms: they enhance insulin secretion when blood glucose levels are elevated, suppress glucagon release (which reduces glucose production by the liver), slow gastric emptying, and promote satiety through effects on appetite centres in the brain

therefore, its combination with a strong CYP3A4 inducer, such as rifampin, should be avoided if possible

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