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21 Despite its efficacy, chronic levodopa use is linked to side effects including wearing-off episodes and levodopa-induced dyskinesias (involuntary erratic movements), impacting up to 80% of patients within 5-10 years of beginning treatment

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References Alzoubi KH, Mayyas FA, Khabour OF, Bani Salama FM, Alhashimi FH, Mhaidat NM (2016) Chronic melatonin treatment prevents memory impairment induced by chronic sleep deprivation