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His desire to find this was in part spurred on by a puzzling phenomenon he observed among some patients who had undergone bariatric surgery, a procedure used to constrict the stomach so that food directly flows into the lower part of the intestine without going through the stomach

This is because the digestive system is very good at breaking down proteins

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PNPLA3 (rs738409, I148M) represents the strongest genetic signal for MAFLD/MASH, promoting hepatic lipid accumulation and inflammation ( For T2DM, risk is elevated by variants in TCF7L2, PPARG, SLC30A8, KCNJ11, and FTO