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Its best to reconstitute only the amount you plan to use within the 4-6 week refrigerated window
doi: 10.1016/j.molmet.2015.07.008 34 CraneJ.McGowanB
However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists
As discussed above, endogenous GLP-1 is rapidly degraded by DPP-4, whereby it loses its insulinotropic activity, and preventing this degradation results in increased intact GLP-1 levels, improved pancreatic islet responses (enhanced insulin and suppressed glucagon levels) and beneficial effects on glucose homeostasis
