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The updated model emphasizes that aging is not driven by a single mechanism, but emerges from a network of interacting biological systems that link molecular damage to systemic physiological decline

Meanwhile, Ozempic goes off patent in Canada next year, and in the US by 2032, potentially opening the door to more affordable access and generic competition

Common injection sites used in trials include: The abdomen (at least 5 cm away from the navel) The upper thigh The upper arm (outer aspect) Rotating injection sites with each weekly dose is recommended to reduce the risk of localised skin reactions such as bruising or injection site discomfort

Thyroid function tests should be rechecked 68 weeks after tirzepatide initiation, and levothyroxine dosing may require adjustment