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Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft
In parallel, animals in the untreated CIM group demonstrated a clear state of oxidative stress, reflected by reduced SOD, CAT, and GPx4 and increased MDA levels, which agrees with prior 5-FU mucositis models in mice and rats (Rtibi et al
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All experiments were carried out with at least three biological replicates
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