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Computational approaches in this domain included: Physiologically-based pharmacokinetic (PBPK) modeling Blood-brain barrier permeability prediction Metabolic stability simulation In silico toxicity assessment Drug-drug interaction prediction These computational predictions helped researchers prioritize compounds with optimal pharmacokinetic profiles before investing in expensive animal studies and clinical trials
The semaglutide Summary of Product Characteristics (SmPC) notes the diabetic retinopathy findings from SUSTAIN-6 and recommends appropriate monitoring for patients with diabetic retinopathy
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