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299,300 Phase 2 trials of once weekly administration of the amylin receptor agonist, eloralintide, in adults with overweight or obesity and without type 2 diabetes have demonstrated significant weight loss, with a mean decrease in body weight ranging from 916%, compared with 0.4% in the placebo group.301 Combination therapy of amylin and semaglutide has also shown promise in weight management, with over 40% of trial participants achieving a decrease in body weight of 25%

GI side effects may temporarily worsen during this escalation but usually resolve within 23 weeks