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In the clinic, we can prescribe two types of incretin-based drugs: glucagon-like peptide 1 receptor agonists (GLP-1RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors
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Developed by Eli Lilly under the compound code LY3437943, retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors a mechanism that distinguishes it from currently approved agents such as semaglutide and tirzepatide
Nutrition and lifestyle counseling and healthy behaviors should be the patients and clinicians foundation to maximize overall benefits and cost-effectiveness of GLP-1s for obesity
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