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"Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial." Press release

Beyond gastrointestinal effects, the following safety signals and class-relevant cautions warrant attention: Heart rate elevation: Retatrutide's glucagon receptor agonism has been associated with modest increases in resting heart rate in Phase 2 data

During weight loss, calorie intake often decreases, which may result in nutrient deficiency if meals are not well-balanced

These three nutrients work together to target problem areas and pack a powerful fat-blasting punch