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23 in placebo MACE-5 (a broader 5-component composite): hazard ratio 0.82 (95% CI 0.551.22) Neither result is statistically significant
It dials up the activity of genes associated with tissue repair and antioxidant production while turning down those linked to inflammation
[1] Other safety considerations include risk of gallbladder disease, pancreatitis, diabetic retinopathy complications (particularly with rapid A1c reduction), and hypersensitivity reactions
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