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Over a median follow-up of 49.5 months, oral semaglutide (up to 14 mg once daily) significantly reduced the risk of major adverse cardiovascular events (MACE) a composite of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke by 14% compared with placebo (hazard ratio 0.86
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Dosage adjustments may be necessary if TSH levels drift outside the therapeutic range
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