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In clinical trials, approximately 20% of people taking semaglutide reported experiencing acid reflux, highlighting it as a common gastrointestinal side effect

Common symptoms The common symptoms of heartburn are: A burning sensation in the chest or upper abdomen that usually starts or worsens after meals or at night Indigestion and abdominal discomfort A sour taste in the throat and mouth Belching or the feeling of acidic food flowing up into the throat Chest discomfort that worsens when lying down or bending forward Related gastrointestinal issues As semaglutide delays digestion, heartburn can appear with related gastrointestinal (GI) side effects

GLP-1 use : Eligible if medically necessary and prescribed

Update June 2026: The Huberman Lab Peptides Episode (Dr