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Weeks 20+: The effects of Semaglutide are most noticeable after 20 weeks (or about five months) of use

That cross-check also exposed a limit, because people remember treatment differently and health records often miss care received elsewhere

They are no longer used as a first add-on in most NICE pathways but still have a role when cost or specific tolerability concerns make newer drugs unsuitable

The cycle-based model also reflects how the GH-axis actually responds clinically: structured ciclos with pauses prevent receptor downregulation, allow IGF-1 to normalize between cycles, and give the provider real data to adjust the next protocol