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They framed the gutbrain axis as a dynamic bidirectional signaling network whose dysregulation underlies a broad spectrum of neurogastrointestinal diseases, positioning EVs as key mediators of intercellular communication and promising non-invasive biomarkers Derived from both host and microbial cells, EVs carry bioactive cargo, including proteins, lipids, nucleic acids, and metabolites, that reflects the physiological or pathological state of their origin and can traverse biological barriers such as the bloodbrain barrier
NICE technology appraisal TA875 (2023) recommends Wegovy within a specialist weight management service for adults with a BMI of 35 kg/m or above (or 30 kg/m in certain high-risk groups) and at least one weight-related health condition, for a maximum of two years
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