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Clinical Pharmacology and Therapeutics

FDA pregnancy risk category reference below: A=No risk B=No risk in some studies C=There may be some risk D=Positive evidence of risk X=Contraindicated N=Unknown Side effects What side effects can occur from Toujeo

Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)

They mimic the action of endogenous glucagon-like peptide 1, a hormone involved in glucose regulation and appetite control