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*Correspondence: Juan Huang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Health technology assessment (Winchester, England) , 13 (27), iii163

Immediate next steps: Mark your calendar for your next dose 7 days from the early dose (not 7 days from your original schedule) Monitor for increased nausea or GI symptoms over the next 48 hours If symptoms worsen significantly, contact your provider Resume your normal 7-day schedule from the new injection day What NOT to do: Don't skip your next dose to "make up" for dosing early (this creates a 14-day gap, which is worse than the one-day compression) Don't take your next dose on your original schedule day (this creates a 6-day interval, compounding the problem) Don't adjust your dose down without provider guidance The single early dose is already in your system

So, to optimize glutathione supplementation, avoid coffee a few hours before or after taking the supplements