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Those same miRNAs also affect tumor suppressor genes.[ref] While a lot more research is needed here, the impact of miRNA on both tumor suppressors and MTHFR may be part of why folate is both beneficial for preventing cancer and then detrimental during some types of cancer
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doi: 10.1172/JCI116186 67 FinanBMaTOttawayNMllerTDHabeggerKMHeppnerKMet al
doi:10.1161/HYPERTENSIONAHA.118.12109 53
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