The primary cellular basis for ototoxic hearing loss is the death of sensory hair cells within the cochlea
The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo
doi: 10.1007/s00394-022-02942-8 104
Natural flavonoids could be broadly categorized into eight classes based on the degree of hybridization of the intermediate carbon atom and the bonding position of the B-ring (at position 2 or 3), including flavonoids, flavonols, dihydroflavonoids, dihydroflavonols, isoflavones, flavan-3-ols, anthocyanins, and chalcones (e.g., baicalin, gambogic acid, puerarin, Fig