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We first examined the concentration-dependent effect of PFOS on mitochondrial bioenergetics and discovered that an increase in the PFOS concentration from 100 to 200 M significantly decreased mitochondrial bioenergetics, as evidenced by the decreased ATP production, maximal respiration and spare respiratory capacity, and increased proton leakage (Fig

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Ripk1 inhibition enhances pirarubicin cytotoxic efficacy through akt-p21-dependent pathway in hepatocellular carcinoma