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GLP-1 receptor agonism has been studied extensively in the context of glucose-stimulated insulin secretion, glucagon suppression, gastric emptying modulation, and appetite-regulating circuits in the central nervous system

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NOVOLOG or human insulin was infused until the patients blood glucose decreased to 36 mg/dL, or until the patient demonstrated signs of hypoglycemia (rise in heart rate and onset of sweating), defined as the time of autonomic reaction (R) (see Figure 3)