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Glutamate and Glutamine Alterations have also been abundantly reported for glutamine and glutamate, pointing towards schizophrenia-induced concentration changes in a time dependent manner: increased glutamine, glutamate and/or the ratio of glutamine-to-glutamate (Gln/Glu) have been found in early stages of the disease and unmedicated patients [22,23,24,25,26,27], whereas decreased levels of these amino acids have often been observed in chronic patients [26, 28,29,30,31]
Endocrine, 87(1), 159-169
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