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These medications can be highly effective, but as their use grows, physicians are seeing more patients experience gallbladder-related symptoms that may be linked to these therapies
Suddenly, the reach of these drugs extended beyond diabetes clinics
Based on the fact that the carboxyl moiety of ibuprofen binds to Arg-120 and Tyr-355 without extending into the side pocket, it was hypothesized that making the carboxyl group longer by adding larger, more rigid groups with hydrogen-bonding functions could enhance the selectivity of ibuprofen while maintaining its ability to reduce pain and inflammation
Retrieved 17 April 2019
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