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On the first day, bilateral vertebral arteries were irreversibly electro-cauterized under anaesthesia with sevoflurane (a mixture of 3.5% sevoflurane in 33% O 2 and 66% N 2 O)

At the time this trial was designed, no study had investigated prolonged high-dose NAC administration during pregnancy, except for a low oral dose NAC (0.6 g/day) trial for up to 20 weeks for recurrent pregnancy loss

Most trials are still ongoing and only one prospective randomized clinical trial with a primary outcome of major cardiovascular events in patients with T2D has reported its results [28]