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[6] This interaction is hypothesized to trigger a cascade of intracellular signaling mechanisms
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[13] The fatty acylcarnitine ester formed then diffuses across the intermembrane space and enters the matrix by facilitated diffusion through carnitine-acylcarnitine translocase (CACT) located on the inner mitochondrial membrane
We reasoned that focusing on the parasites host dependencies would reveal unexplored insights into the cell biology of infection of this deadly parasite, while also uncovering potentially novel therapeutic avenues to improve disease outcomes
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