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(GLP-1 is also made in the brain stem, where it may modify appetite.) It sends a signal to our brain that says, You know, weve had enough to eat, says Drucker
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Gene expression on BDNF and SK-3 was quantified using real-time PCR, revealing that VPA reduced the expression BDNF, which plays a crucial role in synaptic plasticity and neuronal survival, and increased GSK-3, which is involved in neurodevelopment and neuroinflammation whereas crocin dose-dependently normalized both markers (Hosseini et al., 2025)
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