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The medication's primary mechanism of actiontargeting GLP-1 receptors to regulate appetitedoes not directly interfere with neuronal excitability or seizure thresholds in the way that some other medications might

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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

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