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A study shows that GLP-1 receptor agonists show a notably reduced incidence of primary open-angle glaucoma (POAG), ocular hypertension, and the requirement for first-line glaucoma treatments compared to metformin in individuals with type 2 diabetes (80)
In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required
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