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Remarkably, there is evidence that GLP-1 agonists can enhance left ventricular ejection fraction, inotropy, coronary blood flow, cardiac output, and vascular endothelial function because of their cardiovascular effects and decrease overall cardiovascular event risks

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doi:10.1111/j.1749-6632.2003.tb03167.x Pfaus JG, Sadiq A, Spana C, Clayton AH

Besides its role in sleep regulation, melatonin has been researched for its antioxidant properties & potential benefits for skin health, including the treatment of pigmentation disorders like melasma