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The GDF-15 RA use as a potential treatment for obesity stems from observations that elevated tumour-secreted GDF-15 is correlated with WL [99]
These findings identify Alr and PLP homeostasis as therapeutic vulnerabilities that may enable repurposing of DCS against multidrug-resistant bacterial pathogens
Among GLP-1R agonists, liraglutide, semaglutide, and dulaglutide are widely available with licensed indications for the prevention of cardiovascular disease (Marx et al., 2022)
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