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This work was also supported by the National Key Research and Development Program of China (2018YFA0507001, 2018YFA0507000, 2018YFA0508100), the National Natural Science Foundation of China grants 31770898 (G.S.), 31900895 (L.Y.) and 81872915 (M.-W.W.), the National Science and Technology Major Project Key New Drug Creation and Manufacturing Program of China (2018ZX09735-001) and China Postdoctoral Science Foundation (2017M622365)

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These drugs include insulin secretagogues (meglitinides, sulfonylureas), slow- and fast-acting insulin analogues, dipeptidyl peptidase-4 (DPP4) inhibitors, sodium glucose cotransporter 2 (SGLT2) inhibitors, thiazolidinediones, alpha-glucosidase inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists

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Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells

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