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16 It is widely expressed in metabolically active tissues, including the liver, heart, skeletal muscle, and adipose tissue, 2325 and is involved in diverse cellular processes such as metabolic homeostasis, antioxidant defense, autophagy, inflammation, and energy balance

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Persistent symptoms despite 2 weeks of PPI therapy: If omeprazole or similar medications are not controlling your heartburn, your provider may want to perform an endoscopy or pH monitoring to evaluate for complications like Barrett esophagus or esophageal stricture