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One analysis found that tesamorelin reduces visceral adipose tissue with minimal effect on subcutaneous fat (NIH study on tesamorelin and fat)
117 Interestingly, glucagon also exerts insulinotropic effects on islet beta-cells, and this is likely to allow for tissues to uptake glucose and fat once glucagon has induced their catabolism from nutrient storage (as tissues such as skeletal muscle rely on insulin for nutrient uptake from circulation), or the insulinotropic effects of glucagon could simply serve as a feedback inhibition mechanism
Both semaglutide and tirzepatide improve insulin sensitivity, helping your body process glucose more efficiently and reducing fat storage
Patients hear about it more often in the context of tissue repair, mobility, inflammation, and return to activity
