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Their availability in oral and injectable formulations also enhances patient adherence

Caloric needs vary significantly based on age, sex, activity level, and medical conditions

Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare the following: support from Brigham and Womens Hospital, Harvard Medical School, the Netherlands Organization for Scientific Research, Patient-Centered Outcomes Research Institute, Food and Drug Administration, National Institutes of Health, National Institute on Aging, American Diabetes Association for the submitted work

Glycogen stores run out, taking water weight with them: you might drop three to five pounds in the first week from glycogen and water loss, not fat loss