migraine after b12 injection Why Do I Feel Worse My Injection? Understanding Post-Injecti – Oxford Origins Southlake, TX: Botox for Migraines

Both B12 shots and IV infusions bypass the gastrointestinal tract entirely, eliminating this dose-dependent absorption loss

NNMT is an enzyme that methylates nicotinamide (a form of vitamin B3), converting it to N1-methylnicotinamide and effectively removing it from the NAD+ salvage pathway

Once you achieve the desired results with a given dose, you continue taking that dose or a slightly lower one as a maintenance dose to keep the drug level steady in the body and sustain the effect over time without causing toxicity

That enzyme transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide and consuming a molecule of the cell's principal methyl donor in the process