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Fasting insulin levels significantly decreased with tirzepatide (10 mg and 15 mg), and HOMA2-IR, a measure of insulin resistance, significantly decreased with tirzepatide (10 mg) compared to both placebo and dulaglutide
found no significant differences in GH pulse frequency across a 24-hour period between groups with normal GH secretion and those with isolated GHD, noting between eight and eleven GH pulses in both groups
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